5-Hydroxy-9-methylstreptimidone, a new glutarimide from a Streptomyces sp. HIL Y-9065403.

Total syntheses of lactonamycin and lactonamycin Z with late-stage A-ring formation and glycosylation.

and inhibition of drug-resistant influenza virus neuraminidase using anthraquinone-sialic acid hybrids, photodegradation of HIV-1 protease and inhibition of HIV-1 replication in living cells by designed fullerene-sugar hibrids, evaluation of molecular probes based on the 9-methylstreptimidone derivative DTCM-glutarimide, a boron-doped diamond electrode mediated by methoxy radicals, Angew. iodin...

Migrastatin, a new inhibitor of tumor cell migration from Streptomyces sp. MK929-43F1. Taxonomy, fermentation, isolation and biological activities.

A new compound, migrastatin, was isolated from a cultured broth of Streptomyces sp. MK929-43F1, as an inhibitor of tumor cell migration. It was purified by column chromatographies on silica gel and Sephadex LH-20 and HPLC. Migrastatin has the molecular formula of C27H39NO7 consisting of 14-membered macrolide and glutarimide moiety. It inhibited spontaneous migration of human esophageal cancer E...

New glutarimide antibiotics, S-632-B1 and B2. I. Taxonomy of producing strain, fermentation and biological properties.

Strain S-632 was found to produce new glutarimide antibiotics, S-632-B1 and B2, which were isolated from the culture fluid. A taxonomic study on strain S-632 was carried out, and the taxonomic characterization demonstrated that it belonged to the species Streptomyces hygroscopicus. The strain was given the name S. hygroscopicus S-632. These antibiotics were active against Saccharomyces sp., but...

Lactimidomycin, a new glutarimide group antibiotic. Production, isolation, structure and biological activity.

Streptomyces amphibiosporus R310-104 (ATCC 53964) produced a novel antibiotic lactimidomycin which showed inhibitory activity against fungi and prolonged the survival time of mice transplanted with experimental tumors. Structural studies clarified that lactimidomycin is a new glutarimide antibiotic having a unique unsaturated 12-membered lactone ring.

Isolation of 7 beta-(5-hydroxy-5-carboxyvarelamido)-3-hydroxymethyl-3-cephem-4-carboxylic acid from streptomyces sp.